Nimesulide pill

A non-steroidal anti-inflammatory most prescribed drug – Nimesulide that contains dose of 100mg and it’s used for treating acute (short-term) pain, painful osteoarthritis (swelling in the joints), and Primary dysmennorhea (Period Pains).

Nimesuilde is first launched in 1985and currently it’s on the market in worldwide of over 50 countries as orginal product with the trademarks of Nise, Nimopen-MP, Nic-Spas, Nimulid, Nicip, e.t.c.

This trademark also has several products by the brand name of Nimulid, Nise.

Popular NSAID drug Nimesulide is available in various forms including tablets, suppositories, soluble powders, and topical gels.

Nimesulide is a recently developed analgesic, antipyretic and anti-inflammatory agent that differs from conventional nonsteroidal anti-inflammatory drugs both in structure and pharmacological profile. Since nimesulide may be prescribed for patients receiving concomitant medication, the propensity for drug interactions exists.

Major interactions involving interference with drug metabolism have not been described with Nimesulide.

Apart from its anti inflammatory it’s also an analgesic and antipyretic in action, and it’s an ethical medicine suggested to use medicine beneath authorised physician supervision.

Nimesulide benefits

NSAID drug Nimesulide has a favourable benefits and it has proven benefits in the treatment of pain

Medicines containing Nimesulide are on the market since 1985 and are authorised in a number of Member States.

The main purpose of using NImesulide is to treat acute pain, to treat arthritis, and treat primary dysmenorrhoea in adolescents and adults above 12 years old.

Nimesulide dose ought to be taken by prescription of medico and doctor which is able to facilitate to take proper dose for good result. Women should use the drug with caution during lactation and it is contraindicated during pregnancy.

As for alternative NSAIDs the utilization of nimesulide is recommended for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea.

Its complex mode of action offers a unique and broad action on inflammatory processes.

In Addition to that pain relief it also use for Increasing Energy and Improving Skin Tone.

Prescribed pain killer drug

The most prescribed anti-inflamatory drug Nimesulide was first developed by Helsinn Healthcare and is marketed world-wide.

NImesulide is available in the form of tablets (100 mg), granules for oral suspension (100 mg), suppositories (200 mg) and gel (3%).

The anti-inflammatory drug mechanism of Nimesulide should only be prescribed as second line treatment. It provides the fast onset of the analgesic action.

The rapid onset of the analgesic action is crucial for the patients with acute pain and also in case of treatment with systemic NSAIDs

The harmonized indications in the EU are acute pain, primary dysmenorrhoea. The dosage of Nimesulide ought to be used is 100 mg twice daily, the duration prescribed is 15 days to minimize the risk of hepatotoxicity.

The drug must be used under supervision by a licensed physician in accordance with the approved indications. Prescription of the Nimesulide must be based on assessment of the patients’ characteristics and needs. Nimesulide is contraindicated in children below 12 years and in patients suffering from liver problems.

Nimesulide Tablet dose

The main purpose of Nimesulide tablets is for the treatment of painful inflammatory conditions, back pain, dysmenorrhea, postoperative pain, osteoarthritis, and fever.

Oral dosage form in adults :100 mg and In children : 5 mg/kg/day in 2 or 3 divided doses. It is prescribed for the shortest duration.

Nimesulide has superior gastrointestinal safety as compared to other NSAIDs. Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide tablet prevents cancer by inhibiting the proliferation of various types of cancer cells mainly via COX-2 independent mechanisms. It is also used for dry skin, to improve skin-tone,and to increase energy.

Nimesulide is indicated for the treatment of acute pain, Painful osteoarthritis (Swelling in the joints) and primary dysmenorrhoea.

It is considered as the most prescribed tablet for variety of painful inflammatory conditions including those associated with osteoarthritis, postoperative trauma, sports injuries.

Dose: 
The usual dose is 100mg twice a day. 
Children: 5mg/kg of body weight in 2 or 3 divided doses.

 

The maximum duration of a treatment course is 15 days and, as for other NSAIDs, treatment should be as short as possible maximum of 15 days. Nimesulide also improves the skin tone and to increase in energy level.

Food, gender and advanced age have negligible effects on Nimesulide pharmacokinetics.

Nimesulide Indications

Nimesulide medication is a non-steroidal medicinal drug, prescribed for painful inflammatory conditions, back pain, hurting, operative pain, arthritis, and fever.

The various inflammatory conditions like inflammation, sore throat, stomatitis, autoimmune disease, arthritis, low back pain etc., may be treated by Nimesulide pill.

It has a complex mode of action and is characterised by a quick onset of action.

The therapeutic effects of Nimesulide area unit the results of its complete mode of action that targets variety of key mediators of the inflammatory method such as: Cox-2 mediate prostaglandins, free radicals, chemical action enzymes and aminoalkane. Clinical proof is accessible to support a very smart profile in terms of gi tolerability.

It is used for treatment of every type of pains ensuing from sports injury, depression etc.

Nimesulide is indicated in painful inflammatory conditions associated with musculoskeletal system, dysmenorrhoea, Thrombophlebitis, dental pain and in ENT inflammation.

Tablets or Granules: 100 mg twice a day after meals400 mg nimesulide-beta-cyclodextrin Tablets or Granules: 400 mg (= 100 mg nimesulide)twice a day after meals

Suppositories: 200 mg twice a day

Features:

Desirable resultsHelpful and beneficialNo side effectsFast and quick effects Nimesulide 100mg Tablets/granules should be used for the shortest possible duration, as required bythe clinical situation.

Nimesulide forms

The best prescribed Nimesulide tablet is used for the treatment of acute pain, Primary dysmennorhea and also to treat degenerative joint disease.

Forms: A variety of Nimesulide forms are available in the market like in the form of tablets and syrup for oral administration and gels for topical application.
Dose: Nimesulide is available with the dosage of 100 mg for tablets, 100 mg for granules for oral suspension, 200mg for suppositories and 3% of gel.

Nimesulide tablets exerts less gastrointestinal adverse effects than other NSAIDs. It is available in different brands in worldwide among 50 countries.Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which means it provides analgesic (pain-killing) and antipyretic(fever-reducing) effects. Nimesulide is mostly used for treatment of short-term pain(Acute), joint pain (osteoarthritis), period pains (Primary dysmennorhea), Chronic pains and many.

Nimesulide belongs to a class of medications called non-steroidal anti-inflammatory drugs (NSAIDs) which works by blocking the production of prostaglandins (a chemical associated with pain) thereby relieving pain and inflammation.

Dose: Nimesulide is available with the dosage of 100 mg for tablets, 100 mg for granules for oral suspension, 200mg for suppositories and 3% of gel.

Nimesulide is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).

The Gel needed to be applied is three to four times per day depending on the dimension of the affected size and response. Medicalcare ought to be reviewed after 4 weeks.

Nimesulide indications

Anti-inflammatory Analgesics tablet – Nimesulide is very much required for the quick treatment of severe muscular pains and inflammatory problems. NImesulide tablets is available in different countries in the world.

Information:

Nimesulide is indicated in painful inflammatory conditions associated with musculoskeletal system, dysmenorrhoea, Thrombophlebitis, dental pain and in ENT inflammation.

Features:

• Desirable results
• Helpful and beneficial
• No side effects
• Fast and quick effects

Nimesulide 100mg Tablets/granules should be used for the shortest possible duration, as required by

the clinical situation.

 

Indications:

 

Tablets or Granules: 100 mg twice a day after meals

400 mg nimesulide-beta-cyclodextrin Tablets or Granules: 400 mg (= 100 mg nimesulide)

twice a day after meals

Suppositories: 200 mg twice a day

Nimesulide granules

Nimesulide Granules is non-steroidal anti-inflammatory drugs, indicated for the treatment of juvenile chronic arthritis, postoperative pain, acute pain after trauma and primary dysmenorrhea.

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties.

Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.

Active ingredients: nimodipine. Indication: nimesulide granules is non-steroidal anti-inflammatory drugs, indicated for the treatment of juvenile chronic arthritis, postoperative pain, acute pain after trauma and primary dysmenorrhea.

Packaging: 1g / sack; 6, 8, 10 sacks / pack. Contact us for more information.

usage and consumption: oral, the goods only for adults only, a 50 mg to 100 mg daily twice postprandial taking. In accordance with the severity of the conditions and the needs of the patients can be increased to 0.2g, the second service.

elderly patients of the medication should strictly comply with the provisions of doctors. Doctors can reduce under appropriate in the circumstances listed above dosage.

Nimesulide structure

Nimesulide is generally utilized as a part of the treatment of inflammatory torment which hinders the protein cyclooxygenase-2 (COX-2) and has better gastro-intestinal mediocrity in addition to different NSAIDs in its class.

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) This compound, a by-product of p-nitrophenyl methane series sulfa, is structurally a singular non-steroidal anti-inflammatory drug.

It is available in more than 50 countries worldwide.

Features:

• Amongst most effective yet gastro friendly
• Non steroidal anti inflammatory drug (NSAID)
• Nimesulide targets COX-2 an enzyme responsible for inflammation & pain.
• Uses of Nimesulide:
  • Nimesulide tablet has excellent gastrointestinal safety in comparison to other medication.
  • Rapid onset of action within 15 minutes
  • Rapidly relieves pain in arthritis
  Indications:
  • acute pain;
  • primary dysmenorrhoea.

Nimesulide synthesis

Nimesulide, a COX-2 selective drug, possesses anti-inflammatory and analgesic properties. Moreover, it has low gastro-intestinal and renal toxicity.

Its main purpose is to treat acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea .

As for other NSAIDs the use of Nimesulide is preffered for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea. The efficacy of Nimesulide was consistently superior to placebo with its particularly rapid onset action.

Nimesulide is out there in varied forms like Nimesulide Tablets, Nimesulide Powder/granules, Nimesulide Gel, suppositories. Clinical proved that it is available to support a particularly good profile in terms of gastrointestinal tolerability.

Its approved signs are the treatment of intense torment, the symptomatic treatment of osteoarthritis and essential dysmenorrhoea, sports wounds and so on.

Nimesulide is a non-steroidal anti-inflammatory agent that is generally utilized as a part of the treatment of inflammatory torment which hinders the protein cyclooxygenase-2 (COX-2) and has better gastro-intestinal mediocrity in addition to different NSAIDs in its class.

A variety of new Nimesulide derivatives were synthesized through incorporation of a 5-LOX pharmacophore into nimesulide followed with some structural modifications, which were then characterized for dual enzyme inhibitors for these two types of enzymes ((Cyclooxygenase-½ (COX-½) and 5-lipoxygenase (5-LOX) ) ).

 Their structure-activity relationships (SARs) were studied, and compound 20f was found to be an excellent dual enzyme inhibitor.

Nimesulide dosage

The most prescribed pain killer drug- Nimesulide is been available since 1985 with a multifactorial mode of action.

Nimesulide is indicated for the treatment of acute pain, Painful osteoarthritis (Swelling in the joints) and primary dysmenorrhoea.

The maximum duration and dose of a treatment course with nimesulide is recommended with the shortest period of 15 days, 100 mg twice a day, to minimize the risk of hepatotoxicity.

Nimesulide should only be prescribed as second line treatment. The decision to prescribe nimesulide should be based on assessment of the individual patient.

Nimesulide has superior gastrointestinal safety as compared to other NSAIDs. Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide also improves the skin tone and to increase in energy levels. Food, gender and advanced age have negligible effects on Nimesulide pharmacokinetics.

NImesulide is available in the dosage of 100 mgs for tablets, 100 mg for granules for oral suspension, 200mg for suppositories and 3% of gel. 

Nimesulide advantages

The most powerfull painkiller NSAIDs tablet Nimesulide is been available since 1985 and authorised in worldwide over 50 countries.

It has superior gastrointestinal safety as compared to other NSAIDs.

It is available in various forms apart from tablets such as in the form of Gel, powder, and suppositories. It’s also available in several trademarks.

Nimesulide brands such as Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan.

Nimulid is also obtaining in the form of gel.

Nimesulide has superior gastrointestinal safety as compared to other NSAIDs. Its multifactorial mode of action gives it a unique and broad action on inflammatory processes. It has proven benefits in the treatment of Acute (short term) pain, Painful osteoarthritis (swelling in the joints) and primarty dysmennorhea.

Nimesulide Advantages
Nimesulide is an NSAID and a preferential COX II inhibitor. It is a potent analgesic, antipyretic, and potent Anti-Inflammatory action.
It behaves as a competetive inhibitor of histamine release in-vivo and in-vitro, hence posseses antihistaminic and antiallergic properties.

Nimesulide drug interactions

Nimesulide is a recently developed analgesic, antipyretic and anti-inflammatory agent that differs from conventional nonsteroidal anti-inflammatory drugs both in structure and pharmacological profile.

 Since nimesulide may be prescribed for patients receiving concomitant medication, the propensity for drug interactions exists.

Major interactions involving interference with drug metabolism have not been described with Nimesulide.

A marginal decrease in plasma theophylline levels (without changes in respiratory function tests) has been described after addition of Nimesulide to chronic theophylline therapy.

 Nimesulide is available in the market with the dosage of 100mg.

Nimesulide solubility

Nimesulide NSAID’s tablet is an efficient and safe therapeutic selection for the treatment of assorted painful inflammatory conditions like inflammation, sore throat, stomatitis, arthritis, degenerative joint disease, low back pain etc., with a speedy onset of analgesic activity.

The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Nimesulide is soluble in organic solvents like alcohol, DMSO, and dimethyl formamide  (DMF).

Nimesulide is a unique non- steroidal anti-inflammatory drug that acts specifically on cyclo-oxygenase-2 and does not affect cyclo-oxygenase-1. Hence, it exerts its anti-inflammatory action characteristics of non- steroidal anti-inflammatory drug. 

Solubility of Nimesulide Increased on solubilization of drug in semi-polar solvents and non-ionic surfactants.

Solubility of Nimesulide was studied using different cosolvent mixtures and various classes of non-ionic surfactant. Solubility increased drastically (>70 mg/rnl) when polyethylene glycol 300 and polyethylene glycol 400 were used as solvents.

Nimesulide synthesis

Nimesulide is a non-steroidal anti-inflammatory agent that is generally utilized as a part of the treatment of inflammatory torment which hinders the protein cyclooxygenase-2 (COX-2) and has better gastro-intestinal mediocrity in addition to different NSAIDs in its class.

Its approved signs are the treatment of intense torment, the symptomatic treatment of osteoarthritis and essential dysmenorrhoea, sports wounds and so on.

A variety of new Nimesulide derivatives were synthesized through incorporation of a 5-LOX pharmacophore into nimesulide followed with some structural modifications, which were then characterized for dual enzyme inhibitors for these two types of enzymes (Cyclooxygenase-½ (COX-½) and 5-lipoxygenase (5-LOX) ). Their structure-activity relationships (SARs) were studied, and compound 20f was found to be an excellent dual enzyme inhibitor.

Its binding conformation and interaction mode were studied with molecular docking experiments. Compound 20f could become a lead compound for further development for potential anti-inflammatory drugs.

Clinically it has demonstrated that it supports an especially good profile as far as gastrointestinal tolerability.

Nimesulide efficacy

The abilities of NSAID’s drug nimesulide to inhibit COX-2 preferentially and to exert other novel anti-inflammatory actions are consistent with good efficacy and safety and is consistently superior to placebo.

The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Nimesulide must be prescribed by a licensed physician as second line treatment in the approved indications and in compliance with the recommendations

Daily dose is 100mg twice-a-day. As for other NSAIDs the use of nimesulide is recommended for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea.

Nimesulide gel

Nimesulide transdermal gel is a well tolerated novel hydroalcoholic microcarrier based drug delivery system with penetration enhancer. This is cause of superior efficacy of Nimesulide Transdermal Gel.

Nimesulide gel is indicated for a variety of conditions characterized by pain, inflammation and stiffness, such as osteoarthritis, periarthritis, post-traumatic or acute musculoskeletal disorders including tendinitis, tenosynovitis, sprains, strains and low back pain. It Functions by inhibiting particular nerve impulses sent from the periphery to your central system.

Nimesulide is a non-steroidal anti-inflammatory (NSAID) agent which also possess analgesic properties. The product has been formulated using a novel combination of solvents for solubilization of Nimesulide.

Nimesulide exhibited better efficacy it also demonstrated faster onset of action. Significant concentration of Nimesulide could be detected in the blood within 30 minutes of treatment and persisted for 8 hours post treatmen

Nimesulide tablet dose

Nimesulide is indicated for the treatment of acute pain, Painful osteoarthritis (Swelling in the joints) and primary dysmenorrhoea.

It is considered as the most prescribed tablet for variety of painful inflammatory conditions including those associated with osteoarthritis, postoperative trauma, sports injuries.
Dose: 

The usual dose is 100mg twice a day. 
Children: 5mg/kg of body weight in 2 or 3 divided doses. 

The maximum duration of a treatment course is 15 days and, as for other NSAIDs, treatment should be as short as possible maximum of 15 days. Nimesulide also improves the skin tone and to increase in energy level.

Food, gender and advanced age have negligible effects on Nimesulide pharmacokinetics.

NImesulide tablets is also available in the form of Gel which is needed to apply to the affected area, rubbing in a thin layer of the gel 2 to 4 times every day.

Nimesulide composition

Nimesulide is a Non steroidal anti inflammatory drug (NSAID) and targets COX-2 an enzyme responsible for inflammation & pain.

The nimesulide is preferably used in the composition in an amount of 0.1-5% by weight, more preferably in an amount of 0.1-3% by weight, most preferably in an amount of around 1 % by weight of the composition.

This medication is for the most part used as an issue of the treatment of inflammatory torment and also used for postoperative trauma, sports injuries, acute musculoskeletal disorders.

Nimesulide have pain relieving and antipyretic properties which, specially restrains the protein cyclooxygenase-2 (COX-2) and has better gastro-intestinal bearableness in addition to different Nsaids in its class.

Nimesulide combination

The generic Nimesulide combination is manufactured by 399 companies and has nearly 522 Brands of Generics of Nimesulide.

Nimesulide is a Non steroidal anti inflammatory drug (NSAID) and targets COX-2 an enzyme responsible for inflammation & pain.

The Nimesulide is preferably used in the composition in an amount of 0.1-5% by weight, more preferably in an amount of 0.1-3% by weight, most preferably in an amount of around 1 % by weight of the composition.

Some of brands of Nimesulide are:

• Nepar - Nimuselide 100 mg + Paracetamol 500 mg
• Nimular Plus - Nimesulide, Acetaminophen
• Nipar (100 mg) - Nimesulide, Paracetamol
• Abinim-P - Nimesulide 100 mg, paracetamol 500 mg.

Nimesulide is distributed world-wide through a network of selected international partners. 

Nimesulide is mainly used for the treatment of:

• Back Pain 
• Dysmenorrhea
• Osteoarthritis
• Rheumatoid Arthritis

Nimesulide is always recommended to use under a licensed physician supervision